Phenotypic transition
WebDec 22, 2024 · This transition from fibroblast to myofibroblast—a well-known cellular hallmark of the pathological state of tissues—and the environmental stimuli that can induce this transition have received a lot of attention, for example in the contexts of asthma and cardiac fibrosis. ... inducing the completion of the phenotypic transition from proto ... WebOct 11, 2024 · Therapeutic strategies against the VSMC phenotypic transition may improve pathological conditions related to VSMCs and provide a new therapeutic target for preventing and treating AS. The exchange of information between cells is essential for maintaining cell function.
Phenotypic transition
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WebJul 28, 2024 · Zong et al. explored the functional roles of 5′-tiRNA-Cys-GCA as a regulator of phenotypic transition of VSMC by targeting the STAT4 and discussed its protective roles in the onset and progression of aortic dissection. This study provides important insights into the potential value of tiRNAs and provides potential diagnosis biomarker or therapeutic …
WebMay 17, 2011 · A number of studies have reported that vascular smooth muscle cells (VSMCs), the predominant cell type involved in vascular calcification, can undergo phenotypic transition to osteoblastic and chondrocytic cells in a … Web1. a dynamic, ongoing, life-sustaining process by which living organisms adjust to environmental changes. 2. adjustment of the pupil to light. biological adaptation the …
WebAug 7, 2015 · The calcium binding protein S100A4, which was recently proposed as a marker of this phenotypic transition [21], was increased in the aorta of 2-month-old Atg7 F/F SM22α-Cre + mice as compared to ... WebEndothelial-to-mesenchymal transition is defined by the phenotypic transition of ECs to that of mesenchymal cells and is characteristically associated with a loss of EC markers with increased expression of N-cadherin but also vimentin and α-SMA (Zeisberg et al., 2007; Xu-Dubois et al., 2016).
WebThe repeated transition from outcrossing to selfing is a key topic in evolutionary biology. However, the molecular basis of such shifts has been rarely examined due to lack of …
WebTRANSITIONAL PHENOMENA The original concept of transitional phenomena was used by Donald Winnicott to describe the intermediate area of human experience between inner … buffalo chicken bombs recipeWebApr 10, 2024 · TRAPS-seq unravels the phenotypic and transcriptional determinants of pleiotropic T helper 1 (T H 1) cell cytokine secretion (interferon-γ (IFNγ), interleukin-2 (IL-2) and tumor necrosis factor ... buffalo chicken bombs with biscuitsWebPhenotypic screens are designed according to a disease’s characteristic, after which compounds are screened for their ability to improve the illness’s phenotype. ... FM holds a Junior I Award from the Fonds de la Recherche en Santé du Québec and is recipient of a transition grant from the Cole Foundation. Conflict of Interest. FM received ... criterion pub south shieldsWebFeb 21, 2024 · While some mechanistic details remain controversial, EMT is a cell phenotypic transition (CPT) process central to development and pathology. Through time-lapse imaging we recorded single cell trajectories of human A549/Vim-RFP cells undergoing EMT induced by different concentrations of exogenous TGF-β in a multi-dimensional cell … criterion pub bournemouthWebThus, a timely macrophage phenotypic transition from M1 to M2, which allows sufficient M1-mediated inflammation at the early stage of healing, followed by effective anti … buffalo chicken bowl recipeWebFeb 15, 2024 · Compared to Ctl-ab, PD-ab treatment induced suppression of SMC phenotypic transition as evidenced by a decreased relative number of CMC and increased number of SMC, and these effects were ... criterion random forestWebMar 14, 2024 · Mechanical factors such as stress in the extracellular environment are known to affect phenotypic commitment of cells. However, the stress fields experienced by cells … criterion psychometric tests