Cthrc1 fibrosis
WebDec 10, 2024 · Interpretation: We demonstrated that CTHRC1 is a new regulator of liver fibrosis by modulating TGF-β signaling. Targeting CTHRC1 could be a promising therapeutic approach, which can suppress TGF-β signaling and avoid the side effects caused by directly targeting TGF-β. CTHRC1 could also be a potential biomarker for … WebSep 25, 2024 · To determine whether cluster B can be identified in other models of cardiac fibrosis, we examined the presence of CTHRC1 + CFs in a model of chronic cardiac fibrosis generated by infusion of angiotensin …
Cthrc1 fibrosis
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WebTissue stiffness is increased during lung fibrosis, which coincides with a transition of fibroblasts into ACTA2+/CTHRC1+ contractile myofibroblasts that secrete large amounts … WebTreatment of cholestatic fibrosis by altering gene expression of Cthrc1: Implications for autoimmune and non-autoimmune liver disease Author links open overlay panel Zhaolian Bian a 1 , Qi Miao a 1 , Wei Zhong a 1 , Haiyan Zhang a , Qixia Wang a , Yanshen Peng a , Xiaoyu Chen a , Canjie Guo a , Li Shen a , Fan Yang a , Jie Xu a , Dekai Qiu a ...
WebMar 1, 2024 · Comprehensive single-cell analysis and RNA-Seq revealed that the expression of collagen triple helix repeat containing 1 (Cthrc1), a fibrosis … WebNature Genetics 南模生物助力揭示心内膜起源的成纤维细胞调控心脏纤维化. 心力衰竭每年都会导致全球范围内大量的个体致病或死亡。. 在心脏损伤早期,心脏成纤维细胞被激活并分化成具有收缩性的肌成纤维细胞,产生大量的胞外基质,生成富含胶原的疤痕 ...
WebAug 1, 2015 · Collagen triple helix repeat containing-1 (Cthrc1) is a documented specific inhibitor of TGF-β signaling. Based on this observation, we developed the hypothesis that knocking in/knocking out the Cthrc1 gene in murine models of cholestasis would alter the natural history of cholestatic fibrosis. WebFibrosis is mainly triggered by inflammation in various tissues, such as heart and liver tissues, and eventually leads to their subsequent dysfunction. Fibrosis is characterized …
WebJan 11, 2024 · There is evidence to indicate that collagen triple helix repeat containing 1 (CTHRC1), a secreted protein, is involved in many physiological and pathological …
http://www.globalauthorid.com/WebPortal/AuthorCited?wd=GAID10392165&rc=5892E6 daily life of a college athleteWebDec 30, 2024 · Instead, a CTHRC1-high (CTHRC1 hi) fibroblast cluster and a separate HAS-high (HAS hi) cluster emerged in cultured AHLM that were rare in fresh AHLM but enriched in IPF (Fig. 3b, red boxes in Fig ... daily life of a corporate lawyerWebApr 10, 2024 · We recently reported that DT-109 administered orally to mice at 500 mg/kg/day potently reduced steatohepatitis and fibrosis induced by a high-fat, -fructose, and -cholesterol diet (NASH diet). 13 To determine optimal dosing, we evaluated the dose response of DT-109 during NASH. C57BL/6J mice were fed the NASH diet for 12 weeks … daily life of a drug addictWebSep 30, 2016 · CTHRC1 (collagen triple-helix repeat-containing 1), a protein secreted during the tissue-repair process, is highly expressed in several malignant tumors, including pancreatic cancer. We recently ... daily life of a college football playerWebNational Center for Biotechnology Information biolage curly hairWebMay 18, 2024 · Collagen triple helix repeat containing-1 (CTHRC1) is a highly conserved extracellular matrix glycoprotein that is overexpressed in two murine models of cholestatic liver fibrosis. Elevated CTHRC1 has been found to attenuate liver fibrosis in these murine models, thus we aimed to study the expression of CTHRC1 in patients with cholestatic … daily life of a buddhist monkWebSep 23, 2024 · CTHRC1 is a secreted protein involved in a variety of processes, including vascular remodeling, anti-fibrosis, metabolism, and carcinogenesis. ... Wu Q, Yang Q, Sun H. Collagen triple helix repeat containing-1: a novel biomarker associated with disease activity in systemic lupus erythematosus. Lupus. 2024;27(13) ... biolage cream