Cd74 and mif
WebJun 2, 2003 · Using expression cloning and functional analysis, we report the identification of CD74, the cell surface form of the class II–associated invariant chain, as a cell surface … WebCD74 is an HLA class II protein regulating dendritic and macrophage inflammation and is a receptor for macrophage migration inhibitory factor (MIF). CD74 activation induces PI3K-AKT signal transduction and has a role in inflammatory diseases, and thus may be relevant in targeting an immunosuppressive TME of NET/NEC.
Cd74 and mif
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WebMacrophage migration inhibitory factor-1 (MIF1) is a pleiotropic cytokine with known involvement in tumorigenesis. (2–5) MIF1 functions in large part through binding to its … WebDec 30, 2024 · The CD74 and MIF protein were analyzed and matched with HBV-related HCC and non-tumor samples after surgical operation. The mean concentration of CD74 was elevated significantly in the tumor tissues (10.24 ng/mg; 95% CI, 7.81–12.67) when it was compared with non-tumor controls (3.86 ng/mg; 95% CI, 3.09–4.63; P<0.0001, Figure …
WebJun 23, 2024 · CD74 activity is regulated by changes in expression, proteolytic processing, and MIF-interacting proteins that prevent binding … WebJul 22, 2016 · CD74 is expressed on the cell surface of pulmonary macrophages and contributes to macrophage migration inhibitory factor (MIF)-induced inflammatory response in acute lung injury (ALI). A ...
WebSep 1, 2024 · CD74 is the cell surface membrane receptor for the cytokine macrophage migration inhibitory factor (MIF) (Farr et al., 2024). The role of the interaction between … WebMay 9, 2016 · The inhibition of MIF signaling or its receptor CD74 promotes IFN-γ release and amplifies tumor death either through pharmacological inhibition or through siRNA-mediated knockdown. The...
WebOct 17, 2016 · Importantly, CD74 molecule is a cell membrane high-affinity receptor for macrophage migration inhibitory factor (MIF), D-dopachrome tautomerase (D-DT/MIF-2), and bacterial proteins that also behave as an accessory signaling molecule, which undergoes regulated intramembrane proteolysis (RIP) upon its ligand binding [1, 3–6]. In …
WebJun 2, 2003 · Using expression cloning and functional analysis, we report herein that CD74, a Type II transmembrane protein, is a high-affinity binding protein for MIF. MIF binds to … professor ben howdenWebMIF residues 80–87 and Tyr-100 are specific determinants of the interaction between MIF and CD74, whereas Pro-2 of MIF contributes to both MIF/CD74 binding and the MIF/CXCR4 interface 21,22,25. remedy for flem coughWebCD74 is a surface protein expressed on immune cells, which acts as receptor for the chemokine macrophage migration inhibitory factor (MIF). Signaling via the MIF/CD74-axis has been reported to be important for the pathogenesis of chronic lymphocytic leukemia (CLL). We wanted to clarify the role of CD74 in MIF-induced signaling/leukemic … remedy for fleas on catsWebHere we report that a single amino acid substitution (L50Q) in the DR1 domain of the human and mouse DR1-MOG-35-55 constructs (notated as DRhQ and DRmQ, respectively) possessed increased affinity for CD74, a greater capacity to block MIF binding, the ability to inhibit pERK1/2 signaling and increased therapeutic activity in mice with EAE. professor ben green psychiatristWebPrevious work has confirmed that spinal macrophage migration inhibitory factor (MIF) contributes to the pathogenesis of formalin-induced inflammatory hyperalgesia, but the role for MIF in neuropathic pain is still not well defined.METHODS: After approval by the Ethical Committee of Animal Use and Care, the sciatic chronic constriction nerve ... professor ben matthewsWebMar 28, 2024 · A, B, BMDCs were cultured for 72 hours with LPS (5 µg/mL). One million MIF +/+ or MIF −/− (A) and CD74 +/+ or CD74 −/− (B) BMDCs labeled with CFSE or CellVue Far red dyes were mixed in a 1:1 ratio and … remedy for frozen shoulderWebCD74 is a surface protein expressed on immune cells, which acts as receptor for the chemokine macrophage migration inhibitory factor (MIF). Signaling via the MIF/CD74 … remedy for food stuck in throat